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Chỉ định và Liều dùng
Oral
Pain and inflammation associated with musculoskeletal and joint disorders Adult: 250 mg 3 or 4 times daily. Max: 1500 mg daily. Topical/Cutaneous Pain and inflammation associated with musculoskeletal and joint disorders Adult: 3% cream or ointment or 2.5% gel to be applied to affected areas.
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Cách dùng
Should be taken with food. Take w/ or immediately after meals.
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Chống chỉ định
Active peptic ulceration, severe heart failure.
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Thận trọng
Discontinue if hypersensitivity skin reactions occur. Pregnancy, lactation. Elderly, patients with haemorrhagic disorders; hypertension; impaired renal, hepatic, cardiac function; asthma; infections; left ventricular failure; oedema; history of CHF.
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Tác dụng không mong muốn
CNS disturbances, hypersensitivity reactions, renal/hepatic disorders, GI disturbances, cutaneous reactions, agranulocytosis, neutropenia. Fluid retention, photosensitivity, alveolitis, pulmonary eosinophilia, pancreatitis, Stevens-Johnson syndrome, exacerbation of colitis.
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Tương tác
May increase concentration of methotrexate, cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus, diuretics. Increased risk of GI bleeding with corticosteroids, SSRIs, venlafaxine, clopidogrel, ticlopidine, iloprost, erlotinib, sibutramine, alcohol, bisphosphonates, pentoxifylline.
Potentially Fatal: May reduce lithium excretion leading to lithium toxicity. May increase effects of anticoagulants. |
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Tác dụng
Description:
Mechanism of Action: Niflumic acid is an NSAID derived from nicotinic acid. |
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Phân loại MIMS
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